Aren't Nurse Joy and Officer Jenny by definition already "All Grown Up"?
Also, how dark would it be if Pikachu and Meowth were removed and replaced in a nod to our own pet's life expectancy.

They could have used Xbox 8 as reference to its use of Windows 8 and the fact it has an 8 core cpu.

Heck they could have used Xbox 3 because of its 3 OS architecture!