I see your Bashir and O'Brien and raise you one Bashir and Garak.
Often the best friendships are based on learning from difference and
adding novelty to the repertoire. :)

To me, this is the greatest moment of the entire show.

Can't believe those two are still missing.

Bashir and O'Brien.

Names: Xander and Willow

The Doctor and Donna

Xena and Gabrielle. Soul mates, best friends, and BAMFS. Their friendship was unique because though it was tested, most of the series was the both of them supporting one another without resorting to a lot of stupid miscommunication that most tv trots out to "challenge" its characters.

Names: Mal and Zoe, Firefly

Technically, Scott Pilgrim was in his 20s, be he sure acted like an obnoxious teenager. Which, yes, I know, was the point.

Does it help that Lacey Chabert turned really, really, really hot?

Kicking it old school. Little House on the Prairie style for the youngsters.

All the really obnoxious ones have been mentioned, but this guy is still a complete tool:

KIMMY FREAKING GIBBLER.

Sorry Wil Wheaton. I love your show, but you'll never live this down. And for the record, it's more how the character was written than the quality of the actor.

Obnoxious? Certainly. Psychotic? Definitely.

Ill just put this here.

Kai Winn!

truly inspired

It's been said a lot but still must be repeated: