Yep. And you can mention the PSUR too. These safety evaluations are not done in secret. Once out in the market, pharma companies have to track and submit all reported serious adverse events to the health authority of every country where the product is sold. The PSUR also includes a benefit/risk analysis so that a…

Once a drug goes to market the drug company has to compile and submit regular “Periodic safety update reports” that provide a benefit/risk analysis of the drug. Again, from the EMA’s site: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000361.jsp&mid=WC0b01ac058066f910

One of the biggest issues is that during clinical trials the drug is given in a controlled environment to patients with a specific disease and whose other medications are known. Once it is available commercially the control is no longer there. That’s exactly why pharmacovigilance exists.

Great, I’m tearing up just clicking on this damn page. Will have to close my office door and close the blinds before I actually hit play.

Funny, I tried the different angles too. Couldn’t find one that worked. Maybe I should have persevered. That said, I have the Gillette Fusion that vibrates and it’s pretty incredible - as I mentioned above a week-old Gillette blade was better than a fresh Dorco. Maybe the vibration helps.

Funny, I tried the different angles too. Couldn’t find one that worked. Maybe I should have persevered. That said,…

I second this - and I hate to sound like a schill for Gillette. Using a week-old Gillette Fusion blade was far better than a brand new Dorco blade. I had to donate the packs I bought. YMMV of course.

I second this - and I hate to sound like a schill for Gillette. Using a week-old Gillette Fusion blade was far…

I don’t understand. This exact one has been $59.99 for ages, (and isn’t discounted for Cyber Monday) so the Cyber Monday price is not that special.

I don’t understand. This exact one has been $59.99 for ages, (and isn’t discounted for Cyber Monday) so the Cyber…

Why didn’t he just write ‘Drumpf’?

I think this is an excellent infographic that shows not only the depths of the ocean (including the staggering distances involved in the Deepwater Horizon disaster), but also the heights of our mountains. I think Giz showed something similar once. http://www.livescience.com/29536-infographic-tallest-mountain-to-deepe…