In the first episode he started screaming and nearly attacked patrons with a broom, iirc. But yeah, Buscemi almost had me crying with him.

Even if they were to start experimenting with new drugs they'd have to do it in an environment they can control, it's been shown that Pete's outbursts are often, and understandably, violent, so he'd need to be with people who are equipped to manage his basic needs for him during those times.