I’m a VC who invests in pre-clinical and clinical-stage pharmaceutical therapeutics and medical devices, I’m well aware of “how it works.” I assure you, the drug developer couldn’t just “request” a “more diverse” patient population for their studies.

They don’t just “come up” with the dosages. Dosing levels are the product of hundreds of thousands to millions of dollars of animal studies.

Please tell me “/s” means “sarcasm?”

But my point is that it’s not fat shaming. If anything, the author is science shaming, or brain shaming.

Yup, because that’s how the article was written. Not reporting facts, trying to manufacture an evil pharma narrative. I wonder why the media has lost credible in the hearts/minds of regular people.

Fair enough. Frankly, I’m just speculating as to how we ended up where we are.

If journalists want to be taken seriously and earn back the respect of the American populace, this misleading BS needs to stop.

Agreed, but you basically lock your dosing with mice. If you dose .01ml/kg in mice, you can’t go higher in human trials without running new mice models.

It may not be that simple. It may not be safe at certain levels, regardless of the subject’s weight. Or they may just not have ran a dose ranging study at higher dosages.

This is one of the more ignorant things I’ve read on the internet lately, much less from an alleged professional journalist.

What’s interesting is the article discusses weight in absolute terms, not BMI.

Her fault, not the drug company’s. Perhaps she has read some literature that makes her feel comfortable prescribing off label?

“Label” is a term of art in the pharma/device world that basically just means what it’s allowed to be marketed for and what it can be prescribed for (although, if there is literature out there, docs will sometimes prescribe “off label”).

Why was the article written in such a way as to make the manufacturer/drug company out to be the “bad guy” or there was some sort of racial animus/fat shaming happening?

There is one. Shockingly, it haunts the autocross scene in Southern Virginia (Blue Ridge SCCA). It’s red, and appears to be almost entirely stock.

I couldn’t agree more. I saw one yesterday for the first time in a while and I was surprised how good I thought it looked.

Maybe he was just pouring himself a soda.

Which is how we will win WW3

Day, made. Thank you.

Barra is crushing it.