God, grant me the serenity to accept the things I cannot change,

The funny thing about smart people is that if you abuse them, they don't make wonderful things that you can enjoy.

Note we are introduced to the name, "Vain Gloria" as a female Supervillain, but have no specific face to link her to yet.  Note also that Sargent Hatred did indeed protect & spoil Doctor Thaddeus Venture with breakfast and kindly protection as a surprisingly effective bodyguard.  Also note that Sgt. Hatred has indeed…

Ironically "The Pear of Anguish" can be easily substituted with a quick online shopping for some inflatable butt-plugs.
Granted the "The Pear of Anguish" was a medieval anal or oral spreading device (you can bet they didn't care about washing it between uses).
http://en.wikipedia.org/wik…

Well until they come out from the cloning tanks.
Gary: "WAIT WHAT?!? You're ALL CLONES OF #24? This is like Boba Fett all over again."
#24 clone: "Ehh, you saw Doc Venture's lab.  These guys are super-scientist supervillains. Didn't you notice we all looked alike to a creepy level of similarity?"
Gary: "What about Scott…

Well you should consider that Colonel Gentleman is a mix of Sean Connery +
Allan Quatermain.  Now who says that perhaps Colonel Gentleman isn't a MAGICAL character that remains immortal so long as he has sex with people much younger than himself.  The younger person grows a bit older (which is a thing all young dumb…

I personally hoped that Henchman #21 Gary would become the leader of SPHINX which was the Black Ops (infiltrate, identify weakness, set up the enemy for a big fall) extension of the OSI.

Lip-Wrangler?
http://www.youtube.com/watc…

" AAARRR, I Peed" sounds like a racy movie about a pirate with bladder control issues.
And now the parrot is drowning in my piss.

I always thought that accent was from the school of, "I've got a cottonball wadded up in my cheek", diction.
Just imagine him saying the words, "BUFORD T. SCRUGGS".
Now you know the secret of Sheriff J.W. Pepper (played by Clifton James).

Well, Ryan Reynolds does look hot with a beard and a bare chest.
Maybe he'll branch out into a field of acting more suiting his talents.
Gay Porn might have simple enough scripting to hold his interests.

You live on into the future in your genetic code that you pass into your offspring.  These genes determine the fate of the world much more than any stirring parenting speeches.

Be wary, the boys behind the Venture Bros have a motto of making hated characters very popular & interesting.

She can be both.
A woman can only birth one child in one year.
Which explains why Billy the Quizboy is just a bit younger than Thaddeus Venture (the clone) & the Monarch (Rusty Venture) and his albino vampire friend NEVER AGES.

Well, red hair, close friends of the Ventures.  Old enough to be The Monarch's mom.
Both noses doesn't look like either The Monarch or Thaddeus Venture's (clone clone, one of them is a clone at home).

You're seeing, but not looking.
There is a word you're missing called, FORESHADOWING.
Why are scenes included if they're not going to be used later as part of the main plot or as a distraction for the intense fanboys?
HINT HINT.
Billy the Quizboy, son of Rose.
Rose, (as Triple Threat) luscious once-captive of Brainulo (the…

Mentally ill woman throwing pubic hair at a man?
What, is it Sunday again already?
These days the challenge is finding a woman THAT IS NOT SERIOUSLY MESSED UP IN THE HEAD.  Go ahead, I dare you.  All you have to do is scratch any woman's emotional facade a tiny bit and then all of the toilet-seat-position cat-lady-crazy…

One more tidbit on BOGGLE'S DEATH RIDDLE.

No SECURITY CLEARANCE.
 
Although with Mind Erasing machines and devices which can remotely override the consciousness, you'd think that ensuring Security Clearances would be dicey at best.  O.S.I. would have to have some decent gear to protect against a remote mind-control attack (as shown in the "Assisted Suicide"…

And since Gary happily worked for THE MONARCH for decades, he is suddenly trustworthy to be around Doc Venture or the boys Gary kidnapped at one point?