Would you mind expanding upon what you're trying to convey?

IIRC The Man in the High Castle received a bunch of flak for their ill advised advertising plan of dressing up NYC subway cars with 3rd Reich/Imperial Japan imagery.

Ian McShane was David Milichs 3rd choice for Swearengen. He actually wrote the part for Ed O'Neill but HBO, fearful of the ghost of Al Bundy, wouldn't allow him to be cast. Boothe won the role but fell ill and couldn't recover in time for the filming of the pilot, leading to McShane getting the role.

RE: Mr Scorch going megalomaniac, the same thing happened in the pilot with the guy who was previously injected. It could be a side effect of the drug … or (and more likely) I'm giving the writers too much credit.