Family Guy.

Planetfall, at the climax of the game where you have to sacrifice Floyd to repair the colony's machinery. I tried everything possible to see if there was another way first.

Perhaps a series of 5-minute-long shorts on Adult Swim.

It was excellent for group collaboration. It left a lot of the finer details up to the users, so it wasn't apparent that one could do a lot with it, out of the box.