Meh - this joke came after he joked she was slutty “I heard you got sodomized a lot” which in the PC world is equally “not cool”.

Nope, acid will not fuck with your brain unless you already have mental illness. So I would advise you not to take it if you have a history of mental illness in your family history, or if you are younger than 25 or so. By your mid-20s, you will probably know if you’re gonna be schizophrenic. If you’re not worried…

I managed to follow it, and find the point.

Do you?

You should probably do independent research instead of asking a commenter on the Internet.