Vote: Harmony One
Why: Unfortunately discontinued by the manufacturer (Logitech), the Harmony One is a large, very comfortable remote with completely customizable buttons. It also has a touchscreen to pick the desired activity and then to have pages of six “soft” buttons in addition to the physical ones. You can also…

Logitech Harmony One

Easy to program, rechargeable battery, custom lcd screen, hard buttons for dark rooms, comfortable in your hand. I love this remote.