A good example of that would be Elementary. The creators of the show have straight up said from the beginning that Sherlock and Joan won't get together, so instead we get to see a developed platonic relationship and a refreshing take on the Sherlock+Watson friendship. It's great.

Snake Juice was destroyed by the FDA.

Yeah, but that makes sense character wise because Ron is a very private person. It's actually surprising that we haven't saw the triplets until now considering Leslie's personality.