It blocks deep level modding not content replacement mods. Things like Skyrim Script Extender or UI changes are impossible if it is hardcoded which many games do for countless features. If there is something baked into the DRM protected EXE it is impossible to mod. Many graphics, UI, AI, deep level stuff which can…

It blocks dll mods (Skyrim Script Extender type of stuff which is absolutely critical)

This arms race is now blocking single player gamers from cheating via memory editing and blocking all forms of deep level modding such as SKSE (Skyrim Script Extender) which are required for all manner of game changing mods.

You do know that Denuvo is only effective due to anti-VM, anti-analysis, advance persistent threat measures (acts like a virus to hide its tracks), and most important for gamers is prevents modding. (like actual deep modding like Skyrim Script Extender would be impossible with Denuvo)