I see what everyone's saying and, were it not for previous episodes of the show, I'd just see this as another funny gag to be taken lightly. The thing is, I don't think Mindy IS totally okay with it.

Granted, but he's angry about something that has nothing to do with the size of her ass. I know Mindy has often said that it's hard to be a "role model" for women, but she's also said that she prides herself on the unanimous feminism of the members of her writing staff. That said, it seemed uncharacteristic and…

I totally agree with this. The big is completely condescending, and he knows that she's insecure about "this situation". It seemed a low blow, and as much as I LOVED this episode, I REALLY hated that line.