The question is not asking “Does anime exist?” but “Does anime represent reality?”. It would be better phrased as “Is anime reality?”, with the truthful answer “Anime is not reality”. The character asking the question was previously told that the anime she was watching was documentaries of humans, and she has just…

Yes, if the events of this game exist in some world, then the events of various anime series also exist in some world. However, the question is asking whether the events of certain (unnamed and probably fictional) anime series also exist in the world of the game, which is probably false.

Spoiler warning!

It’s not actually meme-related (at least to any memes that existed before the game, that I know of). The character asking the question was originally told that the anime films/episodes they were watching were documentaries on humans, and has now just been told that they were fiction. Said character normally acts in an…

The context of the question is not “Does anime exist?”, but “Does anime portray reality?”. For a bit more background: the character asking the question was originally told that the anime films/episodes they were watching were documentaries on humans, and has now just been told that they were fiction. Said character…

That’s actually due to a quirk of Gen I that Gen II exploited. The “catch rate” of a given ‘mon was stored along with the other data for that ‘mon (for some reason, it’s never used in Gen I), and Gen II used the same slot for the held item. (For catch rates that map to unused/key items, they are changed on first…