If by "missing" you mean leaving for Florida or marrying their middle school sweethearts then yes. But that's a different kind of "missing" entirely.

Do people regularly go missing there? Is there American Gods-style human sacrifices keeping the town locked in unlikely prosperity?

I'll be damned if the Family video in my hometown (Saginaw, MI) is not only still open, but actively hiring and promoting management opportunities. Someone might need to check the Saginaw water as well apparently.