Upright Citizen's Brigade
One of my favorite quotes comes from the "Little Donny" episode, in a scene where he meets the Tite Brothers after their show and gets their autograph. His father asks "What does it say", to which his mother responds "Mama got some big boobies."

Strong Bad's "You just keep doing your thing there, big guy" from the Trogdor e-mail, anytime someone is going about something in an incorrect manner.