I read that final scene with Colin Sweeny the same way. It appeared to me that they had been a couple the whole time (or at least conspiring together the whole time), and everything was a diversion to get the other guy off the ballot. Otherwise, I just don't buy that Isabel would have acted so lovey-dovey (even if it…

Seth MacFarlane's mother died a few years ago from a brain tumor. She had been raised Christian Scientist and had delayed getting treatment, so that must have had some impact on the episode and the writers' treatment of the issue.