I saw someone else put it as, "if you want to imagine that Will and Hannibal did die, then (given what
type of show this is) you can always take the stinger as being
metaphorical: this is the fear that Bedelia will have to live with for
the rest of her life, not knowing whether they survived or not." Which I think is…

if Bedelia did it to herself she lost, lost
herself as much as she lost to Hannibal. To do it to herself that makes her a victim in a way Hannibal alone could never reduce her to. And she was never a victim…she was a stone-cold survivalist, at all costs. It would be completely off-character. In no known universe would…

Neither did I - the last few lines were posted on twitter tonight by Fuller and co. But I honestly don't see how that last scene could be seen as Bedelia doing it to herself. It just so goes against everything we've been presented about her character, ignoring the absolute impossibility of it.

Yeah, but Fuller, the shooting script, and Janice Poon have all said it was Hannibal's doing.
Bedelia has not decided to explore autocannibalism on her own terms.

Now, this show is fantastical, but not to the point that a woman could
pump herself full of drugs and then without medical experience remove
her own leg, neatly bandage her stump, pit-roast a 20+ lb hunk of flesh,
gloriously set the table, fancy herself up, and not even have a crutch
at hand. I mean, c’mon. Seriously.

BEDELIA DID NOT DO THAT TO HERSELF.