The change in Jeremy is both funny, and great. Its great because it was a nice, slow progression. But as soon as i saw this Hunter thing coming, i started noticing things. Like.. in that season and maybe half of the one before it he had started hiding himself in big, baggy clothes, often ill-fitting ones

Basically this. You're seeing the 'discovery' of HIV, and the boom in the death rates, then the sudden drop due to advancements in medical science. Most HIV suffers live very long lives if two things don't happen.

"Wouldn't you do anything for your family" <— Khan.