What we need is pain meds that ONLY target pain. If you take dilaudid, morphine etc, you're pretty out of it. There are targets in research which are based on various natural venoms which hold promise in being incredibly specific. If you're dying of bone cancer, you're in agony. You don't want to be zonked out on a…

Yes, and about time too. But from what I see, this doesn't have those restrictions. I'd be very interested in seeing what harm reduction measures were proposed.

Yes, I've just come back from a quick look on the web. I'm astounded. Truly astounded, that the FDA let this through without at least a nod to abuse reduction (for example the newer OxyContin formulation.)

Yes, it is. Really serious pain is still not addressed adequately by existing meds. They don't seem to have made efforts to make it abuse-resistant (like the newer OxyContin, for example) and that is a serious worry.

Holy mother god. No, they have not. Well, that will escalate quickly.

I work in clinical research, and it's very interesting, but companies do actually look at how "abusable" drugs are. They are looking at ways to make it harder to grind up, snort, inject or cook these capsules. This is a relatively new phenomenom, but I would hope this compound was formulated with this in mind. I'll go…

Yes, that's exactly what my friends who are Spanish tell me. I think history will look back on this and tell us we live in interesting times. At least your weather is decent. I'm a Brit in sweden and oh my goodness... The winters here. So dark...so..so dark.

Hoooo yes. One (ONE) government monopoly sells wine. It's closed at 3 pm on a Saturday and all Sunday. It's been an interesting adjustment for me. I'm a Brit, so I suppose very eccentric and individualistic, and that's very verboten here. On the plus side, I earn 3x my uk salary, everything's clean and safe, gender…

Awful. My sincere sympathies to your sister. I cannot imagine how one rebuilds a life afterwards. I hope whoever did that to her is facing justice ?

Every time a case like this hits the media, I always wonder how many other women are being held like this? I have a horrible, sinking feeling that it's a significant number. My heart goes out to them. How you manage to rebuild a life after an ordeal like that is just unimaginable. And it's always that they have been…

Dark times. I'm lucky to have moved to Sweden, which has largely avoided the euro zone crisis and austerity. What's happening in Spain right now, and really across Southern Europe, is terrible.
I'd be interested to see if you think this is a direct result of the austerity and financial crisis? I know in my native UK…

They have a website, and it's not toooo expensive. Sequencing technology has come down a lot in price. Alzheimer's is a truly brutal disease, as are all forms of dementia. I'm working on a clinical trial with Alzheimer's patients at the moment.
Thing is, we don't really, truly know what causes it. We have a good…

Yeah, most don't. Some can raise the level of tricyclics if you're taking them. Anticonvulsants can really mess with oral contraception... Drug drug interactions are pretty complex sometimes.

St. John's wort can interfere with hormonal contraceptives, in case anyone is thinking of taking it... It does have some clinical efficacy though.

Yup. This deserves to be ungreyed

Honestly I'm not sure... I was spoiled working in a lab. Access to all sorts of stuff... Love the idea of you walloping the stains out with a rolling pin though. That made me giggle.

Nono... I'm not American either :) by meat tenderiser I mean the enzyme mix. It's a liquid. The yellowing is a biological stain, so you need an enzyme to break it down. I used to use a cool enzyme mix from my lab (ahem) but you can buy meat tenderiser. Or any enzymatic cleaner like oxi action will do.

Depends ... For down items, we say no, because the weight of the soaked item can rip the internal baffles that hold the down in place. For this reason, move wet down items very, very carefully. My yearly down item wash is a ritual (live in Sweden, have much down filled clothing.) wash carefully in the bathtub... Then…

Seconded ! I have a real obsession with this sort of thing. Spent a lovely hour today cleaning the sink trap in the bathroom, removing a rat-sized globule of my (horribly thick) hair and pondering the nature of the biofilm on it. I'm a messy, but very clean person... Can cope with untidiness but not filth.

Meat tenderiser. Sounds utterly revolting but it works. The yellowing is biological and you need some good old enzymatic action to break it down. I'm assuming you mean quilt when you say comforter. If you have a down filled duvet, don't use this !