And when he was left alone and aging (in the TARDIS in the Doctor's Wife), it was all HATE AMY DIE AMY KILL AMY.

George and Gracie.
Abbot and Costello.
Laurel and Hardy.
Moe and Curly.
Martin and Lewis.
Reynolds and DeLuise.
The Skipper and Gilligan.
Some might include Kramden and Norton, but I think Ed was smart too oftrn for them to qualify.
Rowan and Martin.